Oleg Zabluda's blog
Saturday, September 30, 2017
"Two recent publications in Nature Communications show in different organisms that the pathways converge in controlling the size and function of nucleoli.

Similarly, the above longevity mutants and nematodes grown under dietary restriction had smaller nucleoli. Moreover, wild-type nematodes show considerable variability in lifespan, and a strong inverse correlation was found between nucleolar size in the first day of adulthood and longevity.
Depletion of fibrillarin also reduced nucleolar size and extended lifespan. Thus, the different longevity pathways converge in the nucleolus, and longevity is associated with reduced ribosome biogenesis.

HGPS-causing (Hutchinson–Gilford progeria syndrome) progerin is sufficient to promote nucleolar expansion. The authors also found a significant correlation between ageing and nucleolar size in healthy individuals;"

0) Live longer with small nucleoli

1) Small nucleoli are a cellular hallmark of longevity

2) Nucleolar expansion and elevated protein translation in premature aging
https://www.nature.com/articles/s41467-017-00322-z """


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